Researchers at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have identified an overworked cog in the cellular machinery of tumor cells that could be targeted by new treatment options for an aggressive class of cancers. The team found that blocking this system with known drugs selectively killed these cancers—those linked to mutations in a set of genes known as RAS—and caused mouse tumors to shrink, suggesting a new strategy for tackling cancers that often resist treatment.
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