While they share similar depressive and cognitive symptoms, the biological underpinnings of bipolar disorder and major depressive disorder are distinct. A novel study appearing in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is the first to identify clinically relevant pathways linking metabolic dysfunction, brain structure, and cognition in mood disorders, with stronger and more specific effects observed in bipolar disorder. It highlights the potential of targeting metabolic pathways to improve cognitive symptoms in bipolar disorder.
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