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Home Health Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases

Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases

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In autoimmune disorders, immune cells targeting “self” proteins are mistakenly activated, resulting in abnormal expansion and responsiveness. These disorders are known to reduce patients’ quality of life over a prolonged period. This can be attributed to CD4+ T cells, which play a key role in inducing persistent inflammation, recruiting other immune cells, including antibody-producing B cells, and inflicting tissue damage.

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