Ordinary fat cells in obese animals can be induced to burn energy stores, generating substantial heat, according to a preclinical study by Weill Cornell Medicine investigators. In the study, published in Nature Metabolism, the researchers showed that in fat cells called white adipocytes, high levels of fatty acids from fat stores, in the presence of a key enzyme called AAC, can trigger a process that uses fat to produce heat and increase energy expenditure. They demonstrated that this process can occur in obese mice—implying that it could yield significant weight loss over time.
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