Sex-specific differences in blood-brain barrier may elucidate why women face greater depression risk

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Women are affected by severe depression twice as often as men. The reasons for this have not yet been fully clarified. One potential factor is sex-specific differences in the blood-brain barrier. This barrier is formed by astrocytes (widely branching cells in the brain) and endothelial cells (flat cells that line the blood vessels). If the barrier is leaky, diseases of the brain can develop.

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