A large review of opioid pain relievers prescribed for acute pain has found these medicines provide only small, short-term relief for some acute conditions and are ineffective for some others. The study set out to review the efficacy and harms of opioid pain relievers (e.g. codeine, morphine, oxycodone, tramadol) compared with placebo for acute pain. The work includes 59 systematic reviews covering more than 50 acute pain conditions in children and adults, and comprehensively maps where opioids are effective and where evidence is lacking.
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