Researchers from the MPI of Biochemistry and the Technical University of Munich have discovered new diagnostic markers for multiple sclerosis (MS), a disease that affects 3 million people worldwide. Using mass spectrometry, about 1,500 proteins were analyzed simultaneously per sample in the cerebrospinal fluid (CSF) of 5,000 patients. The study, published in Cell, uncovered a set of marker proteins that improve differentiation of MS from other inflammatory brain diseases where classical MS markers are negative. The study identified changes in the CSF proteome that may potentially predict disease progression. This approach could also open up new avenues for the diagnosis of other diseases.
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