Nerve growth factor (NGF) is a specialized protein, also called a neurotrophin, that is critical for the development and survival of nerves responsible for our senses and the body’s fight-or-flight response. While the presence of NGF is crucial during the embryonic stage, its presence in adults is often an indication of inflammation, as it is a key mediator of pain for conditions like osteoarthritis (OA). Now, a study published in Arthritis & Rheumatology shows that NGF is much more than a pain messenger—it can actually change the structure of a joint.
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