Scientists have created a new “molecular map” uncovering how an important human receptor involved in blood clotting and inflammation works—an advance that could help us design better drugs for conditions such as pulmonary arterial hypertension, cardiovascular disease, and certain cancers. The study, led by an international team including researchers from Trinity College Dublin and published in Nature Communications, used advanced cryo-electron microscopy to capture high-res images of the thromboxane A2 receptor while it was active and primed to send signals across the membrane to the cell interior.
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