New research from the University of Newcastle has found that people with irritable bowel syndrome (IBS) show detectable biological changes, challenging the long-held perception that the condition lacks a physical basis. The large-scale systematic review and meta-analysis combined data from 124 studies involving nearly 15,000 people. It found that individuals with IBS exhibit signs of low-grade inflammation and immune system activation compared to healthy individuals. The paper is published in the journal eBioMedicine.
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