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Dynamic gel helps scientists grow organs more reliably in the lab

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Miniature organs grown in the lab can organize themselves into complex shapes. But they never do it the same way twice, which makes it hard to use these so-called “organoids” to study disease. Now, scientists at UC San Francisco have created a new material that helps organoids grow in a more predictable way. They mixed microparticles of alginate, a complex carbohydrate derived from algae, into Matrigel, the standard gel used to grow organoids. This made the gel more akin to the soft but supportive environment inside the body that tissues normally grow in.

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