Down syndrome is caused by an extra copy of chromosome 21. Because of genes present on this chromosome that are known to contribute to Alzheimer’s disease, patients with Down syndrome often develop the disease, sometimes at a relatively young age. However, few studies have examined Alzheimer’s-related pathological changes in the brains of people with Down syndrome, especially pediatric patients and those who are Black or Hispanic. Studies also hadn’t explored other neurodegenerative conditions in those with Down syndrome.
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