People with ulcerative colitis (UC), a chronic inflammatory bowel disease, are up to four times more likely to develop colorectal cancer than the general population. Low-grade dysplasia (LGD)—abnormal or precancerous lesions—can be an early warning sign, but only a fraction of UC-LGD cases progress to cancer. This makes it challenging for clinicians and patients to make informed care decisions, ranging from continued surveillance to preventative surgery.
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