Researchers at the University of Liège have identified a key genetic regulator that enables macrophages to reach full maturity and preserve the health of our organs. The MafB factor, a veritable “molecular switch,” activates or deactivates certain genes at the right time and in the right place, leading to the production of macrophages responsible for defending our body and supporting the functioning of our organs. Without MafB, macrophages can become dysfunctional, no longer performing their beneficial roles properly. The work appears in the journal Immunity.
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