Why energy transport in the heart fails in hypertrophic cardiomyopathy

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Hypertrophic cardiomyopathy (HCM) is the most common hereditary heart disease. It causes the left ventricle to thicken, the heart muscle to contract too strongly and work too hard. This additional strain puts pressure on the cells’ power plants, the mitochondria, and can increase the risk of dangerous cardiac arrhythmias. Creatine kinase plays a key role in maintaining the balance between energy consumption and production (energy homeostasis). This enzyme helps the heart to recycle energy quickly so that each heartbeat receives the energy it needs.

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